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A well untapped

Finally managed to tick off one of those aggravating perpetually-delayed items on Ye Ol’ To-Do-List — poring through most of Muhammad Yunus’s wonderful book on the foundations of microcredit in the developing world, Banker to the Poor. The belatedness was even more irksome this time since yours truly got it as a gift, with that all-too-slippery “I’ll definitely read this” pledge issued both to giver and self. (Thank goodness for prolonged shift changes and those holiday-weekend traffic jams that force you off the road to a seedy diner in Mid-Nowhere with nothing to do but finally plow through that long-delayed promise-I’ll-read-it tome that you’ve been cuefully keeping in your frayed old briefcase. Hey, wait, that’s just me?)

What’s most striking about Dr. Yunus’s opus is the emotional juxtaposition that rattles in your head as you turn the pages, especially about halfway through. On the one hand, it’s inspiring in that rare, 200-proof antidote to cynicism kind of way, to glimpse both the author’s determination (and acumen) in implementing such an innovative system, and the opportunities suddenly materializing to countless people otherwise stuck in the kind of vicious-cycle destitution that drives away lenders and begets more of the same. On the other hand, you can’t help but be mentally clothes-lined by a nasty sense of boundless wasted potential, which quickly transmogrifies into one of those Freakonomics-ish suspicions that our standard economic metrics tend to miss something really fundamental here. 

What Dr. Yunus and his colleagues achieved with their microcredit efforts was an incipient, often crude, yet genuine realization of the same aim that blazes trails for us in fields like bioinformatics or operations research: collating and unleashing the wisdom of the crowd. The structures that Dr. Yunus established for micro-lending — heck, his belief in its prospects alone — were openly mocked, largely because few could conceive of the added value that would be generated by the networks so created. Whether explicit or not, however, Dr. Yunus’s key insight was that the wellspring of value in the micro-lending networks was a core source of wealth creation that had been hitherto largely ignored: the local knowledge and subtle, often intangible communications networks among the people (particularly the women) in even the poorest of villages in the Third World. His microcredit, in effect, became a catalyst to break the “activation energy barrier” (chem analogies never die) that prevented this latent wealth from transforming into more palpable, easily-quantified economic networks.

So what’s the indispensable lesson-of-the-day to take home and chew on here? Well, it’s something with a far more global and geopolitical significance than the book’s local color might initially suggest.

Consider this Public Policy Puzzler for a moment: How can we reliably judge the viability of a country’s economic, social, and political system? This may sound like one of those questions with a 1,001 valid answers, but there’s probably a simple and elegant test to gain at least a rough gauge of an answer: Can said nation maintain its fiscal standing and social stability in the absence of natural resources? Historically, the wealth of nations has been inextricably linked to the commodities that they could mine or dig up on their own soil, or the commodities they could mine or dig up on someone else’s soil (aka imperialism). Even if you’re not a card-carrying member of Club Peak Oil, it’s undeniable that for the first time in human history, those resources are running out across the board, and our economies can no longer depend on them. Unfortunately, many of the implicit economic assumptions that underlie the world’s societies are based on a presumption of natural plenitude. This is especially true of a once-frontier nation like the United States, which had not only abundant land but also (well into the 1950s) the enviable status of being the world’s largest oil producer. 

Therein lies the rub — we can’t create much wealth with the dig-ables and the mine-ables anymore, so where does it come from? The answer is, well, it’s wicked tough. To date, there are really only a handful of nations that have managed this difficult feat: the Scandinavian countries and Finland, South Korea, Germany, Estonia, the Czech Republic, Taiwan, Singapore, Japan, Austria, Switzerland, and a handful of other countries clustered mostly on the Pacific Rim or Central Europe. What do they have in common? They’ve held on to their manufacturing and refused to outsource their high-tech industries, they’re “social capitalist” (Steven Hill’s term) mixed economies in design, they have heavy investment and subsidies in human capital (esp through education and health care), and they’ve managed a delicate balance of vigorous entrepreneurialism with social cohesion and community solidarity. In other words, their wealth stems in effect from the same source that Dr. Yunus learned so cleverly to tap: sophisticated and evolving networks of human knowledge and communication in tight-knit communities. And lest we be tempted to minimize the tangible value of these structures, consider that Germany — population at about 83 million or so — despite having almost no natural resources, has the world’s second-largest export economy, behind only China (population 1.3 billion) and larger than ours in the US (population roughly 320 million). 

What we’re glimpsing with these scattered examples are the first hints of economically-viable systems in a resource-poor world. And “glimpsing” is used deliberately here: In effect, economies across the globe will increasingly be depending on their ability to better connect up and harness the individual minds of their citizens, to engender the kind of “collective mind” that far exceeds the sum of its parts, or even what we can fathom as individuals.

If you want to get all philosoph-y about this challenge, it beats a path straight back to Mr. Epistemology himself, Professor Immanuel Kant (and to an extent, even to Leibniz before him). I’ve scribbled on this topic before, but one of the most pivotal implications of Kant’s often mind-scrambling work is that the most valuable knowledge is often “noumenal” to us, outside of the “phenomenal” perception availed by our individual cone of awareness. This is even true of our own individual knowledge and capabilities. Think about those instances when you’ve pulled off a feat you could never have imagined yourself doing, given that speech you thought was out of your league, set out to write a piece that seemed to write itself. (Trust me, you’ve pulled this off at some point even if you never explicitly patted yourself on the back from it.) There’s a reason for that: It’s simply not possible for our individual minds to fully grasp the extent of their own capabilities. In fact, staying in the kind of zone that makes us capable of pulling them off, often requires that we not be explicitly aware of them at all.

If our minds can never be fully cognizant of their own capacities, now consider the bar that’s set for comprehending those of a group of independently-acting, yet collaborating individuals. The potential is immense, and the structures we’ve assembled to tap this largely untapped wealth — from brainstorming sessions to sophisticated informatics systems — barely dip the bucket below the surface. One of the great challenges of our era is to develop better organizational systems to nurture and harness this added value. After all, our very societies may depend on them.

— J. Wes Ulm

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Okay, we know, we know, it’s shameless self promotion. We will be  using the increased traffic from our website to fund this donation. We  will be sending Red Cross the check for the Japan Earthquake and Pacific  Tsunami.
UPDATE: We forgot to add what we’d do if someone were to “like” the  post. We will combine the reblogs and likes we got from our last post  along with the reblogs and likes we get from this post.
We wish we can donate more, but it’s all we can handle. If you would like to donate directly to the cause, please click here.
We will be donating 1 cent per every reblog, 1 cent for every like and 5 cents per every new  follower we get. We’ll be sending the check to American Red Cross.
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EDIT! Hopefully this will get enough notes, but if it gets too many, we’d have to stop it at 50000!

viasquared:

1000 reblogs = $10

10000 reblogs = $100 .. and so on

Okay, we know, we know, it’s shameless self promotion. We will be using the increased traffic from our website to fund this donation. We will be sending Red Cross the check for the Japan Earthquake and Pacific Tsunami.

UPDATE: We forgot to add what we’d do if someone were to “like” the post. We will combine the reblogs and likes we got from our last post along with the reblogs and likes we get from this post.

We wish we can donate more, but it’s all we can handle. If you would like to donate directly to the cause, please click here.

We will be donating 1 cent per every reblog, 1 cent for every like and 5 cents per every new follower we get. We’ll be sending the check to American Red Cross.

Email us at what@viaSQUARED.com for any questions regarding this.

EDIT! Hopefully this will get enough notes, but if it gets too many, we’d have to stop it at 50000!

Thanks to themoldycucumber and Huffpo for this.

Condolences to Japan

It’s like the tragedy of the Kobe earthquake in 1995 all over again, and it’s no less painful to behold today. Our thoughts and prayers are with the Japanese people, and it;s heartening to see that the international community— including China, no doubt recalling its own anguish from the 2008 tremor in Sichuan— has come so quickly to their aid.

Those Saturday-morning rush-hour blues…

Oh, Interstate 5, how I fear and loathe thee…

Had a gig recently on Saturday morning, and had to take the long trek way down the I-5 toward Santa Ana. Working on the country’s designated morning for goofing-off and catching-up-on-lost-sleep isn’t exactly the most pleasant start to the weekend, but it’s nothing unusual in the teaching/medical/research side of things. What’s becoming almost unbearable, though, is the prospect of facing those hideous stretches of 5 p.m.-style stop-and-go traffic. On a Saturday. At 9 a.m. I kid you not.

(Seriously, it wasn’t much better than this.)

It’s like the transportational equivalent of bottled-up Antichrist-scale evil, opened up and sprinkled right down on your friendly neighborhood Interstate. Now, SoCal roadways are of course infamous for being eviller in general than your analogously clogged thoroughfares in Sioux City or Duluth, but even they tend to have mercy on us hapless Asphalt Crawlers on the weekends. But not the I-5. Not just in comparison to other 4-lane dungeons in the country (Boston and the D.C. area can be almost as painful), but compared to other hideously jammed-up Cali freeways (I’m looking at you, downtown Rte. 110 and 101 just about anywhere), the I-5 is a little bit of sun-baked hell on earth, even on the weekends.

It’s interesting and more than a little disturbing, in that curiously antiseptic epidemiological study kind-of-way, that severely clogged freeways can be almost as stress-inducing as an actual heart attack. Measurements of blood catecholamine and glucocorticoid release (basically the hormonal markers of the short-term and somewhat longer-term fight-or-flight response, i.e. how one part of your body tells another part of the body that THERE’S A SABER-TOOTHED TIGER RIGHT IN FRONT OF US, RUN! RUN!) are about the same in each case. Which says that the concrete jungles in many of our under-subwayed urban centers may be literally hazardous to one’s health. (Bad enough in general, and if your lungs also tend to do their best curled-up armadillo impression in such circumstances… ah, the joys of alpha-meditation and stim when the whole world around you is blurring into a cacophonous little pandemonium of honking horns and bad attitudes in a Hummer. That and a not-so-relaxing puff of the inhaler…)

Honestly, it’s just cruel, inhumane, atrocious to face a rush hour on a Saturday morning. It’s, like, a fundamental affront to the Geneva Conventions or something. Like a torturous distortion of all that’s good and right in our Enlightenment-inspired society, a regression to feudal serfdom in a four-wheeled fief. And it’s made even worse when you’ve gone through your last books-on-tape and EVERY SINGLE RADIO STATION is going on about Charlie Sheen’s latest… whatever all that’s about, I couldn’t listen to more than ten seconds of it without getting that unhealthy forehead-slapping feeling and shutting the radio off in relief. 

So I’m swearing off the I-5 from now on. It’ll be getting perpetually lost somewhere on Firestone or Beach Blvd from now on, pestering a million harried gas-station owners to figure out those reasonably safe (or maybe not so much) back routes that the truckers and other secret-society types maintain as part of their secret pact of secret and sacred knowledge with each other. That’s right, Wes is gatecrashing the inner sanctum of Forbidden Roadie Knowledge, even if I have to sacrifice a few more tanks of $4 gas to get it. Or maybe I could just stop being such an accidental Jack-Kerouac wannabe Luddite and buy the damn GPS that all my friends keep hassling me about…

What I’m (re-)reading now

1. Passionate Minds: The Inner World of Scientists by Lewis Wolpert and Alison Richards. A fave 10 years ago and a fave just the same today. Difficult to encapsulate how fascinating, useful, insightful, and just all-around enlightening this book is. The authors spoke with 23 prominent researchers and physicians (some of them Nobel Laureates, others public figures in their own right), essentially to gain a rarefied window into the minds of the people who open windows into nature for the rest of us. It’s something akin to that NPR radio show, Fresh Air (with Terry Gross), that I’m sure has been a welcome accompaniment to more than a few of us while stuck in a car-sandwich in some urban jungle during rush hour. The show interviews world-renowned actors, musicians, athletes, and other figures, about their background and how they actually accomplished what’s brought them to the public forefront. The show’s a perennial hit, if for no other reason than its basic insight: These formidable artists and celebrity personalities generally had to stumble through the same uncertainties and tedium as anyone else (alongside the obligatory right-place-at-the-right-time breaks and connections), to forge their skills and gain even a pittance of attention for their talent. So the show is both humbling and enlightening at the same time.

Passionate Minds does this for the scientific community. When you browse the articles on figures like Roald Hoffmann, Gerald Edelman, Carlo Rubbia, and Anne McLaren among others, you see that these groundbreakers for the most part had maybe a handful of truly brilliant epiphanies and insights— combined with a forest’s worth of groping around and stumbling before they arrived at them. But they were invariably persistent and resilient, and when some anomalous observation came along that hinted at nature’s hidden cleverness, they pressed themselves to match it with their own cleverness so as to shed light on the phenomenon. The scientific method, at its core, is above all a rigorous methodology to establish true causation as opposed to the far more common correlation of a process and the factors that potentially give rise to it. (Which is also why it advances so gradually, primarily via basic research, and requires so many years to suss out something genuine.)

The figures in Passionate Minds had conditioned themselves from years of intuition-building to pick out something significant, then to design a system that could prove (or refute) their suspicions. I’d suspect that Andrew Fire and Craig Mello (co-discoverers of the RNAi phenomenon) would be featured in a new edition today, given that their breakthrough— which is now guiding or enhancing thousands of clinically-relevant projects in molecular biology— began with little more than anomalous findings in the color of a cultivated petunia. Well worth a read and then many re-reads thereafter.

2. The Lives of a Cell by Lewis Thomas. The still (deservedly) cherished essay compilation by Dr. Thomas, collected from his articles in The New England Journal of Medicine. Since he wrote on so many diverse topics, it’s difficult to pinpoint a single theme in the book, but his insights (this was back in the mid-1970s or so) were uncannily farsighted and outside-the-box. One of my favorite themes (which has worked its way into my own writing) is the notion of the noosphere, as developed by Vladimir Vernadsky and Pierre Teilhard de Chardin, and itself anchored chiefly in the original postulates of Leibniz— a kind of variant on evolutionary theory, rooted in the stepwise evolution of communication, memory, and general cognition (both within animal nervous systems and outside of them). It’s a practical (and quite clearly, economically significant) concept as much as a theoretical interest, and to the extent that The Lives of a Cell has a unifying undercurrent, these sorts of Leibnizian ruminations seem to be driving it. Dr. Thomas effectively anticipates modern developments like the Internet, but its core— making it a gem for anyone in the medical field— is a thought-provoking series of meditations on biology at the micro- and macro-levels alike, with a treasure-hunter’s eye for hidden connections between seemingly unrelated phenomena in the natural world. The still-fledgling ideas of information theory as a basis for cellular processes (and even many psychological ones) are hinted at more than once by Dr. Thomas’s impressive prescience.

Also: Just about anything by Heinlein, Lee Smolin, Gregory Chaitin, and (whenever I can sneak it in) some old-fashioned Gothic fiction (Horace Walpole and Ann Radcliffe— gotta start with the classics). This all may seem like a strange brew, but that’s the nourishing elixir for original writing (and occasionally even brainstorm fodder for the research proposal). That, and a little Chemical Brothers, Muse, or Collective Soul stirring in the background…

Happy Turkey/Tofurkey Day everyone!

Enjoy the holiday!

A chance to cut = a chance to cure?

Just tossing this out, in case anyone has firsthand experience that could shine a little light on the topic. There’s a surgical procedure recently developed to reduce the complications of asthma/RAD, called bronchial thermoplasty. It’s potentially curative, the first such approach to physically debulk some of the smooth muscle that coils around the aiirways, causing so much of the misery that we all know and dread… (A summary of clinical data and some reviews w/ PDF links here and here. Not that many review articles yet, unfortunately, and even fewer available without a journal subscription.) 

Anyway, the long and short of it: The published literature suggests that the technique is in one of those maddening preliminary zones, when there’s a mountain of data to suggest a breakthrough but not yet enough to narrow down the ideal patient pool (including early-onset vs. acquired later, non-trivial issue), rule out side effects in certain subpopulations, or substantiate the early promise. That also means it’s controversial even among the specialists in the field. So it’s understandably an out-of-pocket thing right now for the most part, without guarantee of success. 

Just askin’— has anyone actually undergone this? Given the so far inadequate and/or conflicting data and the at-best shaky consensus among specialists in the know, even those us with a med background don’t have much concrete to go on, other than personal attestations by those who’ve gone through it. But given a choice between an unproven (but potentially invaluable) trip to the OR and the prospect of more breathing through that straw in the chest in the wrong surroundings (not to mention going all bubble-boy when someone nearby has a chest cold)…

Anyway, if anyone’s run the gauntlet on this and would be willing to share, I’d be grateful to hear from you. Temp contact here (sorry, gotta fend off those spambots): wesulm at hotmail  Thx in advance.

The Knowledge Aggregator primer is up

Just a quick FYI to those of you who’ve queried me about it (which means that 99% of y’all can blissfully ignore this): I’ve posted up a sample from the condensed and excerpted description of my proposal for the Kantian Knowledge Aggregator  (“Kantische Wissensaggregator”) on my alterna-homepage here. (Also here if any trouble with that link: http://tinyurl.com/28kceqb ) I’ve omitted most of the agonizing technical specs from my primary docs, but even the abridged project description here covers a pretty thick 9 pages, so this is strictly aficionado material. The primer has an abstract as well as the basic background (technical and epistemological) behind the system, and an overview of the structure for the “discovery machine” or whatever tagline I was using to talk the thing up. There’s also a more at-length discussion of the overarching objective— harnessing group creative drive as a sort of emergent property (in generating value-added modalities for diagnosis and treatment), as well as three “canonical problems” to establish at least the rudiments for proof-of-principle: spinal cord repair, positive-negative selection systems for molecular cancer therapy, and cost-effective biomarkers for early-onset heart disease.

The approach here is more along the lines of econ and/or operations research, both for the old-fashioned Bayesian systems and the more untested open-ended modalities, but it’s definitely geared toward a subset of biomedical questions, so I’ve concluded with some specific examples. Feel free to cite any passages you find helpful; these documents are all official and copyrighted, even the public-domain primer, so just make sure to cobble together a semi-official citation with the standard boilerplate (including page #) if you want to make a reference to it.

Just one other reminder: Again, the original version of all these documents (including the link above) is in German; I’ve been developing this as a trans-Atlantic thing, and the first applications are geared for a network of institutions in Miteleuropa. So I’m in the weird and frequently annoying position of having to translate my own seminal documents for the project back into my own native tongue, which I’ve been too busy and/or lazy to do up to this point. But I know some of you said you can handle the text regardless (and there’s always Babelfish/Intertran/Google Translate to get a first pass), so hopefully this’ll tide you over as I get the translated versions up and running. I’ll of course keep you duly updated as this (hopefully) gets closer to the proof-of-concept phase.

Friday Catblogging: Now this you don’t see too often…

Four-leaf clovers. Total eclipses. Hell freezing over. Santa Claus and the Easter Bunny. An open lane on the 405 or I-10 during rush hour. What do they all have in common? They’re all far better-documented phenomena than the scene below:

Yes, three felines all encroaching upon each other’s personal space, without flying fur or bared fangs. It’s an old pic so my apologies for the basically nonexistent picture quality, but the sheer rarity of the event required that it be frozen in photographic amber for posterity. That’s Topaz in the back. The amorphous black blob in the middle is Rex all curled up, with Scooter tending the store on the right. Not shown: The mountain of catnip smuggled in to make it all possible. Photographer takes no responsibility for unobserved inter-feline interactions when said catnip wore off.